Steroids. III

Transcortin: a corticosteroid-binding protein of plasma. III. The effects of various steroids.

16-substituted Steroids Iii. the Partial Synthesis of Estriol by Max N. Huffman

Estriol was originally obtained (1930) by isolation from human pregnancy urine by Marrian (1) and by Doisy et al. (2). Both Doisy (2) and Marrian (3) showed that estriol differed from estrone, another estrogenic hormone occurring in gravid urine, in possessing three acetylizable hydroxyl groups instead of the one hydroxyl and one carbonyl. Butenandt (4) soon (1931) proved that estriol might be ...

Anabolic steroids.

Athletes, like others, use recreational and lorillicit psychoactive drugs. However, many athletes also use drugs to enhance their training or performance, including an array of bizarre and exotic substances. Although the majority of these substances are not psychoactive, they may be abused by athletes. Some of these substances, such as anabolic steroids and human growth honnone, are referred to...

Anabolic steroids.

The term "anabolic steroids" refers to testosterone derivatives that are used either clinically or by athletes for their anabolic properties. However, scientists have questioned the anabolic effects of testosterone and its derivatives in normal men for decades. Most scientists concluded that anabolic steroids do not increase muscle size or strength in people with normal gonadal function and hav...

Ignoring steroids

A new study by Ito and colleagues on page 7 may help explain why patients with a severe lung disease called chronic obstructive pulmonary disease (COPD) fail to respond to steroid treatment. Ito and colleagues show that steroids require the enzyme HDAC2 (histone deacetylase 2) to block the inflammatory transcription factor NF-κB. In patients with COPD, HDAC2 activity is reduced, rendering cells...